The notorious Black Death was a catastrophic bubonic plague that started to spread massively across Europe and Asia in the middle of the 14th century. According to History, some 20 million people would perish within a span of only five years. The gradual onset of symptoms generally entailed massive black boils (hence the name) that would expel pus and blood, followed by fever, chills, vomiting, diarrhea, joint pain, and more unpleasantness, until the sickness became too much for the infected person to handle. Death was more or less inevitable.
While the most devastating outbreak of the Black Death happened in the mid-1300s, it periodically reappeared over subsequent centuries, as History reports. Around 300 years after its original surge across the Eastern hemisphere, it came back once again and took the city of London, England by pestilential storm (via Mental Floss).
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